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C8960
Sigma-Aldrich Caffeine
SigmaUltra
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Synonym 1,3,7-Trimethylxanthine
Molecular FormulaC8H10N4O2
Molecular Weight194.19
CAS Number 58-08-2 Beilstein Registry Number 17705
EG/EC Number 2003621
MDL number MFCD00005758
PubChem Substance ID 24893117
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Price and Availability
Product
Number Your Price
CZK Available to Ship Quantity Actions
C8960-250G 3059,50 28.10.2007 In Stock from Schnelldorf 28.10.2007
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C8960-1KG 9048,00 28.10.2007 In Stock from Schnelldorf 28.10.2007
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Descriptions
Biochem/physiol Actions A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Properties
grade SigmaUltra
total impurities <0.0005% Phosphorus (P)
<0.1% Insoluble matter
ign. residue <0.1%
mp 234-236.5 °C (lit.)
solubility chloroform: 0.5 M at 20 °C, clear, colorless
anion traces chloride (Cl-): <0.05%
sulfate (SO42-): <0.05%
cation traces Al: <0.0005%
Ca: <0.001%
Cu: <0.0005%
Fe: <0.0005%
K: <0.005%
Mg: <0.001%
NH4+: <0.05%
Na: <0.005%
Pb: <0.001%
Zn: <0.0005%
Gene Information human ... ADORA1 (134), PDE4B (5142)
References
Reference Hadfield, M.G., Caffeine and the olfactory bulb. Mol. Neurobiol. 15, 31-39, (1997)
Shafer, S.H., et al., Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem. Pharmacol. 56, 1229-1236, (1998)
He, A.W., and Cory, J.G., p53-independent anisomycin induced G1 arrest and apoptosis in L1210 cell lines. Anticancer Res. 19, 421-428, (1999)
Takagi, M., et al., DNA damage-associated cell cycle and cell death control is differentially modulated by caffeine in clones with p53 mutations. Leukemia 13, 70-77, (1999)
Poe, B.S., and O'Neill, K.L., Caffeine modulates heat shock induced apoptosis in the human promyelocytic leukemia cell line HL-60. Cancer Lett. 121, 1-6, (1997)
Islam, M.S., et al., In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation. Proc. Natl. Acad. Sci. USA 95, 6145-6150, (1998)
Ferre, S., et al., Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 20, 482-487, (1997)
Merck Merck 13,1636
Beilstein Beil. 26,461 / Beil. 26,IV,2338
reference Aldrich MSDS 1, 343:A / Corp MSDS 1 (1), 664:C / FT-IR 2 (3), 3668:B / FT-IR 1 (2), 710:B / IR-Spectra (3), 1287:D / IR-Spectra (2), 1120:B / NMR-Reference 2 (2), 586:A / RegBook 1 (2), 2467:A / Sax 6, 615 / Sigma FT-IR 1 (1), 581:A / Structure Index 1, 390:E:3
Safety
Hazard Codes Xn
Risk Statements 22
RIDADR UN 1544 6.1/PG 3
WGK Germany 1
RTECS EV6475000
F 10
je to kvalitní zdroj...i když ne to nejlepší co jde sehnat...dražší suroviny se používají v analytice...pro biologii...nebo biochemii to ale stačí