Pro ty co umi anglicky
Krealkalyne patent
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=/netahtml/search-bool.html&r=2&f=G&l=50&co1=AND&d=ptxt&s1=6399661&OS=6399661&RS=6399661
http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=18806&zoneid=28
Kre-alkalyn® supplementation has no beneficial effect on
creatine-to-creatinine conversion rates.
Tallon MJ (1) and Child R (2)
(1)University of Northumbria, Sport Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne, United Kingdom,
(2)Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom.
DrTallon@CR-Technologies.net
All American Pharmaceutical and Natural Foods Corp. (Billings, MT, USA) claim that
Kre-alkalyn® (KA) a “Buffered”
creatine, is 100% stable in stomach acid and does not convert to
creatinine. In contrast, they also claim that
creatine monohydrate (CM) is highly pH labile with more than 90% of the
creatine converting to the degradation product
creatinine in stomach acids. To date, no independent or university laboratory has evaluated the stability of KA in stomach acids, assessed its possible conversion to
creatinine, or made direct comparisons of acid stability with CM.
This study examined whether KA supplementation reduced the rate of
creatine conversion to
creatinine, relative to commercially available CM (Creapure).
Creatine products were analyzed by an independent commercial laboratory using testing guidelines recommended by the United States Pharmacopeia (USP). Each product was incubated in 900ml of pH 1 HCL at 37± 1oC and samples where drawn at 5, 30 and 120 minutes and immediately analyzed by HPLC (UV) for
creatine and
creatinine.
In contrast to the claims of All American Pharmaceutical and Natural Foods Corp., the rate of
creatinine formation from CM was found to be less than 1% of the initial dose, demonstrating that CM is extremely stable under acidic conditions that replicate those of the stomach. This study also showed that KA supplementation actually resulted in 35% greater conversion of
creatine to
creatinine than CM. In conclusion the conversion of
creatine to
creatinine is not a limitation in the delivery of
creatine from CM and KA is less stable than CM in the acid conditions of the stomach.
Creatine ethyl ester rapidly degrades to
creatinine in stomach acid
Child R1 and Tallon MJ2
(1)Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom.
(2)University of Northumbria, Sport Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne, United Kingdom,
DrChild@CR-Technologies.net
Creatine ethyl ester (CEE) is a commercially available synthetic
creatine that is now widely used in dietary supplements. It comprises of
creatine with an ethyl group attached and this molecular configuration is reported to provide several advantages over
creatine monohydrate (CM). The Medical Research Institute (CA, USA) claim that the CEE in their product (CE2) provides greater solubility in lipids, leading to improved absorption. Similarly San (San Corporation, CA, USA) claim that the CEE in their product (San CM2 Alpha) avoids the breakdown of
creatine to
creatinine in stomach acids. Ultimately it is claimed that CEE products provide greater absorption and efficacy than CM. To date, none of these claims have been evaluated by an independent, or university laboratory and no comparative data are available on CEE and CM.
This study assessed the availability of
creatine from three commercial
creatine products during degradation in acidic conditions similar to those that occur in the stomach. They comprised of two products containing CEE (San CM2 Alpha and CE2) and commercially available CM (CreapureÒ). An independent laboratory, using testing guidelines recommended by the United States Pharmacopeia (USP), performed the analysis. Each product was incubated in 900ml of pH 1 HCL at 37± 1oC and samples where drawn at 5, 30 and 120 minutes.
Creatine availability was assessed by immediately assaying for free
creatine, CEE and the
creatine breakdown product
creatinine, using HPLC (UV)
After 30 minutes incubation only 73% of the initial CEE present was available from CE2, while the amount of CEE available from San CM2 Alpha was even lower at only 62%. In contrast, more than 99% of the
creatine remained available from the CM product. These reductions in CEE availability were accompanied by substantial
creatinine formation, without the appearance of free
creatine. After 120minutes incubation 72% of the CEE was available from CE2 with only 11% available from San CM2 Alpha, while more than 99% of the
creatine remained available from CM.
CEE is claimed to provide several advantages over CM because of increased solubility and stability. In practice, the addition of the ethyl group to
creatine actually reduces acid stability and accelerates its breakdown to
creatinine. This substantially reduces
creatine availability in its esterified form and as a consequence
creatines such as San CM2 and CE2 are inferior to CM as a source of free
creatine.
Nastavení
Registrace
Přihlášení/Login
a nasycovaci fazy jsi mel?takze stejne pak po ten nasycovacce beres to,co jsi napsal? neni to moc? 
tim hur,jestli bere 
Kdyby ho clovek bral bez nahravaci faze,bude stacit dat na regeneraci 5 g ihned po cviceni?
například 400g monohydrátu od champion nutrition stojí 900kč a např od 
